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Aphanizomenon
flos aquae (AFA) is very high in chlorophyll. Cancer
research has shown chlorophyll to be a very powerful
therapeutic for cancer, chemo-prevention and chemo-therapeutics.
Klamath Blue Green Algae, (AFA) is a cyanobacteria that
contains approximately 600mg/100g of chlorophyll.
The chlorophyll in AFA is free in the cytoplasm, not
bound to the chloroplast, making Klamath Blue Green
Algae high in chlorophyll that is readily available
to metabolize.
The change of a cell from a normal to cancerous cell
can be caused by a simple point mutation in the DNA
sequence. Each of the 3-billion nucleotide combinations
in the human genome can experience mutation. The
types of mutations (frameshifts, translocations, inversions,
deletions or insertional activations) and the location
of mutations in the chromosomes have
been determined to be key in the onset and progression
of cancer.
Research
has identified 98 genes that are oncogenes, cancer genes or
tumor suppressor genes. When mutations of these 98 genes occur,
the stage is set for the onset of cancer to begin. For example,
the OMIM database sponsored by the NIH (P53, record #19170)
registers 120 research articles that discuss the P53 gene and
its role in an array of human cancers. Research is now
being done on the ability of chlorophyll to play a key role
in the cell's ability to repair this damage (18, and currently
unpublished work). The ability of chlorophyll to conduct gene
splicing on DNA molecules with wrong gene sequencing is being
discovered. The research implies that chlorophyll may
reduce the error formation in DNA, utilizing an error-prone
repair system on damaged DNA.
Many
contributing factors create different cellular mutations that
have caused cancer. Tumor initiation, promotion and enhancement
are responsible for increased expression of cancer and can be
caused or enabled by:
*
Genetic predisposition and gender
*
Dietary and environmental exposures to carcinogens
*
Genetic alterations from overexposure to certain frequencies
in the electro magnetic spectrum (radioactive exposure, x-rays,
gamma rays or ultraviolet light).
*
Attacks on the genetic structure by viruses (like Epstein-Barr)
Chlorophyll
can assist with the effects of dietary and environmental exposure
to carcinogens. Research indicates that chlorophyll reduces
carcinogen binding to DNA in the target organ by inhibition
of carcinogen activation enzyme or degradation of ultimate carcinogens
with the target cells (2,3,5,17). Inhibiting the activity
of the enzyme that attack the DNA sequence, significantly reduces
the incidence of mutagenicity and reduces the onset of cancer.
This research shows noncompetitive inhibition of carcinogenic
enzymes by chlorophyll. Dietary inhibitors of mutagenesis
and carcinogenesis are of interest because they may be used
for human cancer prevention and treatment. Chlorophyll
has demonstrated to be a carcinorgenesis inhibitor in the gut
(2,3,5). There is research that shows there is sufficient systemic
chlorophyll distribution for these inhibitory mechanisms to
be operative beyond the gut and in the whole animal. This
study analyzed chemoprotection in benzo(a)pyrene-initiated mouse
skin tumorigenesis (11). Oral administration of chlorophyll
has been studied for the last 50 years. All of the research
conducted by Dr. Bailey at OSU point to the necessity of high
levels of oral ingestion of chlorophyll for the chemo-therapeutic
effects of chlorophyll to be effective (2,3,5). A.F.A.,
Inc. believes that by increasing the purity of the oral therapeutic
by the order of 3X by utilizing pure chlorophyll, the required
dosage needed to be effective will be reduced.
Another
important property of chlorophyll is its potential to reduce
metastasis. Chlorophyll has been shown to take an active
part in controlling the enzymes that are involved in mitosis.
By controlling this rapid cell division chemically, the rapid
onset of tumors can be reduced significantly, potentially giving
the cell the ability to repair itself (8,10,13,14). In addition
to being locally efficacious, this reduces the chances of tumor
cells being transferred to other parts of the body.
For
many years cancer patients have resisted conventional chemotherapy
and have experienced successful remissions of various cancers
by ingesting large amounts of freshly juiced wheat grass and
or algae. It is our belief that the chlorophyll is being
metabolized stopping tumor growth and assisting in cellular
repair of the DNA, in these self-treatment regimes. We
have many testimonials of people who have utilized Klamath Blue
Green Algae in this self-treatment regime.
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A.F.A., Inc. and Power Organics surpass all Upper Klamath Lake Harvesters in methods that retain high chlorophyll. Chlorophyll
breaks down very easily. Isomers, esters and phorbibes
are created due to changes in pH, light and temperature. A.F.A.,
Inc. quality control has been aware of these changes and has
pioneered in a harvesting methodology that eliminates these
breakdown products. We are the only Upper Klamath Lake Harvester
with on board refrigeration to ensure this high quality product.
Our three-stage refrigeration system utilized in harvesting
the algae provides assurances of the chlorophyll quality:
1.
* Algae is pumped out of Klamath Lake into a double insulated
refrigerated tank on the harvester awaiting transport to the
shore.
2.
* Algae is pumped into a double insulated refrigeration tank
on the shore waiting filtering and dewatering.
3.
* Algae is immediately frozen in a blast freezer after filtering
and dewatering.
* No
other Upper Klamath Lake Harvester has any of the above three
systems.
*A.F.A.,
Inc. and Power Organics go to the necessary steps to provide
a powerful and healthy product.*
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References:
1.
Baxter, J.H., Absorption of chlorophyll phytol in normal men
and in patients with Refsum's disearse, J. Lipid Res, 9, 636-641
2.
Breinholt,V., Hendricks, J., Pereira, C, Arbogast, D.,and Bailey,
G., 1995, Dietary Chlorophyllin is a Potent inhibitor of Aflatoxin
B Hepatocarcinogenesis in Rainbow Trout, J. Cancer Research,
55, 57-62
3.
Breinholt, V., Schimerlik, M., Dashwood, R., and Bailey, G.,
1995, Mechanisms of Chlorophyllin Anticarcinogenesis against
Aflatoxin B: Complex Formation with the Carcinogen, Chem. Res.
Toxicol., Vol. 8, No 4
4.
Dashwood, R.H., 1992, Protection by chlorophyllin against the
covalent binding of 2-amino-3-methylimidazo {4,5-f}quinoline
(IQ) to rat liver DNA, Carcinogenesis, 13, 112-118
5.
Dashwood, R.H., Breinholt, V., and Bailey, G.S., 1991, Chemopreventative
properties of chlorophyllin: inhibition of aflatoxin-B- DNA
binding in vivo and antimutagenic activity against AFB and two
heterocyclic amines in the Salmonella mutagenicity assay, Carcinogenesis,
12, 939-942
6.
Ghosh, A., Sen, S., Sharma, A., and Talukder, G., 1991, Inhibitions
of clastogenic effects of cesium chloride in mice in vivo by
chloropyllin, Toxicol. Lett., 57, 17-Nov
7.
Ghosh, A., Sen.,S., Sharma, A. and Takukder, G., 1991, Effect
of chlorophyllin mercury chloride induced clastogenicity in
mice, Food Chem. Toxicol., 29, 777-779
8.
Imai, K., Aimoto, T., Sato, M., Watanabe, K., Kimura, R., and
Murato, T., 1986, Effects of soduim metallochlorophyllins on
the activity and components of the microsomal drug-metabolizing
enzyme system in rat liver, Chem. Pharm. Bull., 34, 4287-4293
9.
Lahitova, M., Doupovcova, J., Zvonar, J., Chandoga, J., and
Hogman, G., 1994, Antimutagenic Properties of Fresh-Water Blue-Green
Algae, Follia Microbiol., 39(4), 301-303
10.
Oda, T., Yokono, O., Yosida, A., Miyake, K. and Iino, S., 1971,
On the successful treatment of pancreatitis, Gastroenterol,
Japan, 6, 49-54
11.
Park, K.K., Surh, Y-J., Stewart, B.C., and Miller, J.A., 1994,
Chemoprotective activities of chlorophyllin: Inhibition of mutagenicity
and covalent binding of various ultimate carcinogens, Proc.
Am. Assoc. Cancer Res., 35, 139
12.
Robbins, E.W., and Nelson, R.L., 1989, Inhibition of 1,2 dimethylhydrazine-induced
nuclear damage in rat colonic epithelium by chlorophyllin, Anticancer
Res., 9, 981-986
13.
Sato, M., Konagai, K., Kuwana, T., Kimura, R., and Murata, T.,
1984, Effects of sodium copper chlorophyllin on lipid peroxidation
VII. Effects of its administration on the stability of
rat liver lysosomes., Chem. Pharm. Bull, 32, 2855-2858
14.
Sato, M., Imai, K., Kimura, R., and Murata, T., 1984, Effect
of sodium copper chlorophyllin on lipid peroxidation.
VI Effects of it's administration on mitochondrial and
microsomal lipid peroxidation in rat liver, Chem. Pharm. Bull.,
32, 712-722
15. Schwartz, J., Shklar, G., Reid,
S. and Trickler, D., 1988, Preventionof Experimental Oral cancer
by Extracts of Spriulina-Dunaliella Algae, Nutrition and Cancer,
127-134
16.
Shklar, G. and Schwartz, J., 1988, Tumor Necrosis Factor in
Experimental Cancer Regression with Alphatocopherol, Beta- Carotene,
Canthaxanthin and Algae Extract, J. Cancer Clinical Oncol, 24
(5), 839-850
17. Tachino, N., Guo, D., Dashwood,
W.M. Yamane, S., Larsen, R., and Dashwood, R.H., 1994, Mechanisms
in the in vitro antimutagenic action of chlorophyllin against
benzo{a}pyrene: Studies of enzyme inhibition, molecular
complex formation and degradation of the utlimate carcinogen,
Mutat. Res., 308, 191-302
18.
Whong, W., Stewart, J., Brockman, H.E., and Ong T., 1988, Comparative
antimutagenicity of chlorophyllin and five other agents against
aflatoxin B induce reversion in Salmonella typhimurium TA98,
Teratog., Carcinog. Mutagen, 8, 215-224
19.
Wu, A.L., Chen, J.F., Ong.T., Brockman, H.E. and Whong, W.A.,
1994, Antitransforming activity of chlorophyllin against selected
carcinogens and complex mixtures, Teratog., Carcinog. Mutagen,
14, 75-81 |
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